Description

Product Overview

Melanotan 2 (MT-II) Peptide is a synthetic cyclic analog of α-melanocyte-stimulating hormone (α-MSH) that has become one of the most extensively investigated melanocortin receptor agonists in peptide research. Owing to its enhanced structural stability and receptor affinity, MT-II serves as a valuable experimental molecule for studying melanocortin receptor biology, receptor pharmacology, and peptide-mediated cellular signaling.

Researchers employ Melanotan 2 to investigate interactions with melanocortin receptor subtypes, particularly MC1R, while also exploring receptor activity involving MC3R, MC4R, and MC5R in controlled laboratory models. Scientific investigations examine intracellular signaling pathways associated with cyclic AMP (cAMP), melanogenesis, pigment regulation, receptor activation kinetics, and GPCR-mediated molecular communication. Additional research explores UV-responsive cellular mechanisms, transcriptional regulation, and peptide-receptor interactions across multiple biological systems.

At Appex Peptide Lab, Melanotan 2 (MT-II) Peptide is manufactured under rigorous quality-controlled conditions using validated synthesis and purification protocols. Every batch undergoes comprehensive analytical verification to ensure exceptional purity, molecular integrity, and batch reproducibility before release.

Trusted by universities, biotechnology companies, pharmaceutical developers, and peptide science laboratories throughout the United States, Canada, and Australia, MT-II provides dependable quality for advanced melanocortin signaling and molecular biology research.

Key Research Highlights

• Premium research-grade Melanotan 2 (MT-II)
• Synthetic cyclic melanocortin receptor agonist
• High-purity lyophilized peptide
• Third-party laboratory tested
• HPLC purity verification
• Certificate of Analysis (COA) included
• Batch-tested for reproducibility
• Suitable for melanocortin receptor investigations
• Optimized for pigmentation signaling research
• Stable formulation for laboratory applications
• Secure laboratory packaging
• Fast shipping to the USA, Canada, and Australia

Why Researchers Choose This Product

Researchers studying melanocortin biology require peptide standards that provide exceptional analytical quality and reproducible laboratory performance.

Researchers choose this product because it offers:

• High analytical purity
• Verified peptide identity
• Independent third-party laboratory testing
• Excellent batch-to-batch consistency
• Stable lyophilized formulation
• Comprehensive analytical documentation
• Reliable manufacturing standards
• Trusted by peptide pharmacology laboratories
• Optimized for receptor biology research
• Suitable for advanced GPCR investigations

Research Applications

Melanocortin Receptor Biology

Laboratory investigations examining MC1R, MC3R, MC4R, and MC5R activation, ligand binding, receptor trafficking, and intracellular signaling.

Pigmentation Signaling Research

Experimental studies evaluating melanocyte biology, melanin biosynthesis pathways, and pigment-related cellular communication.

GPCR Pharmacology

Research focused on G protein-coupled receptor activation, ligand specificity, receptor selectivity, and signaling kinetics.

UV Response Modeling

Investigations exploring cellular responses to ultraviolet exposure, photobiology, and pigment-associated molecular pathways.

Molecular Pharmacology

Studies involving receptor-ligand interactions, peptide stability, structure-activity relationships, and receptor pharmacodynamics.

Cellular Signaling

Experimental research evaluating cAMP production, protein kinase activation, transcription factor regulation, and intracellular messenger systems.

Peptide Chemistry

Laboratory investigations involving cyclic peptide stability, molecular optimization, conformational analysis, and synthetic peptide characterization.

Neuroscience and Endocrine Research

Studies examining melanocortin signaling networks, neuroendocrine communication, and peptide-mediated receptor biology.

Product Specifications

Mechanism of Action

Within laboratory research, Melanotan 2 (MT-II) Peptide is investigated as a potent synthetic agonist of the melanocortin receptor (MCR) family, a group of Class A G protein-coupled receptors (GPCRs) involved in numerous physiological signaling pathways. MT-II exhibits high affinity for multiple receptor subtypes, including MC1R, MC3R, MC4R, and MC5R, allowing researchers to evaluate receptor-specific signaling mechanisms across diverse experimental models.

Upon receptor binding, MT-II primarily activates Gs protein-dependent signaling, stimulating adenylyl cyclase and increasing intracellular cyclic adenosine monophosphate (cAMP) concentrations. Elevated cAMP activates downstream signaling mediators such as protein kinase A (PKA) and cAMP-responsive transcription factors, enabling researchers to investigate molecular events associated with melanocortin receptor activation and intracellular signal transduction.

In melanocyte-based laboratory models, activation of MC1R is extensively studied for its influence on transcriptional regulation involving microphthalmia-associated transcription factor (MITF) and downstream enzymes associated with melanogenesis, including tyrosinase (TYR), TRP-1, and TRP-2. Experimental investigations focus on receptor-mediated gene expression, pigment synthesis pathways, and cellular responses to ultraviolet radiation within controlled research environments.

The cyclic peptide structure of MT-II enhances conformational stability and resistance to enzymatic degradation compared with endogenous α-melanocyte-stimulating hormone (α-MSH). Researchers therefore utilize MT-II to examine receptor binding kinetics, peptide stability, receptor internalization, β-arrestin recruitment, and GPCR signaling dynamics. Additional studies explore melanocortin-mediated neuroendocrine signaling, intracellular kinase activation, peptide pharmacology, and structure-activity relationships.

Because of its well-characterized receptor profile and reproducible pharmacological properties, Melanotan 2 remains a valuable research molecule for investigations in peptide chemistry, melanocortin receptor biology, molecular pharmacology, cellular signaling, and experimental physiology.

For research use only. Not intended for human consumption or clinical use.