Description

ARA-290 (Cibinetide) Peptide for Advanced Innate Repair Receptor and Cellular Signaling Research

ARA-290 (Cibinetide) Peptide is a synthetic peptide engineered from the helix-B surface of erythropoietin (EPO) while excluding the structural domains responsible for activation of the classical erythropoietin receptor involved in red blood cell production. This selective design enables researchers to investigate non-erythropoietic EPO signaling pathways through activation of the Innate Repair Receptor (IRR), a heteromeric receptor complex composed of the erythropoietin receptor (EPOR) and the β-common receptor (CD131).

Scientific investigations have utilized ARA-290 Peptide in laboratory studies examining receptor pharmacology, intracellular signal transduction, cytokine regulation, oxidative stress responses, mitochondrial function, apoptosis, and mechanisms involved in cellular adaptation to physiological stress. Because it selectively targets IRR-mediated pathways, ARA-290 has become an important experimental reagent for studying tissue-protective signaling independently of erythropoiesis.

Researchers across neuroscience, immunology, molecular pharmacology, regenerative biology, and peptide chemistry continue to investigate ARA-290 using cellular, biochemical, and preclinical models to better understand receptor activation, inflammatory signaling networks, and peptide-mediated communication.

Each batch is synthesized under stringent quality-controlled manufacturing conditions, analytically verified for purity and sequence identity, and supplied as a stable lyophilized peptide with a comprehensive Certificate of Analysis to ensure reproducible laboratory performance.

For research use only. Not intended for human consumption or clinical use.

Key Research Highlights

• Synthetic peptide derived from the helix-B domain of erythropoietin
• Selective activator of the Innate Repair Receptor (IRR)
• Does not activate classical erythropoietic signaling pathways in laboratory models
• Investigated in receptor pharmacology and intracellular signaling research
• Frequently utilized in cytokine and inflammatory pathway investigations
• Evaluated in apoptosis and cellular stress response studies
• Incorporated into oxidative stress and mitochondrial biology research
• High-purity lyophilized peptide suitable for laboratory applications
• Certificate of Analysis (COA) supplied with every batch
• Manufactured under rigorous analytical quality standards
• Excellent batch-to-batch reproducibility
• Suitable for biotechnology, pharmaceutical, and academic research laboratories

Why Researchers Choose This Product

• ≥99% research-grade purity verified through analytical testing
• Verified peptide sequence and structural identity
• High selectivity for Innate Repair Receptor signaling
• Stable lyophilized formulation for laboratory storage
• Comprehensive Certificate of Analysis included
• Reliable reproducibility across experimental studies
• Suitable for molecular biology, immunology, and peptide pharmacology research
• Manufactured using rigorous peptide synthesis protocols
• Available in research-grade laboratory quantities
• Intended exclusively for scientific laboratory investigations

Research Applications

Innate Repair Receptor Research

ARA-290 (Cibinetide) Peptide is extensively utilized in laboratory investigations examining activation of the Innate Repair Receptor (IRR), receptor selectivity, and downstream intracellular signaling mechanisms.

Cellular Signal Transduction

Researchers employ ARA-290 to investigate JAK/STAT signaling, PI3K/Akt activation, MAPK/ERK pathways, transcriptional regulation, and peptide-mediated intracellular communication.

Cytokine Signaling Research

Experimental models utilize ARA-290 to evaluate regulation of inflammatory mediators, cytokine expression, chemokine signaling, and immune-related molecular pathways under controlled laboratory conditions.

Mitochondrial Biology

Scientists investigate mitochondrial homeostasis, oxidative stress regulation, reactive oxygen species signaling, and cellular bioenergetics using ARA-290 in mechanistic research models.

Apoptosis and Cell Survival Studies

Laboratory investigations incorporate ARA-290 to examine molecular mechanisms regulating programmed cell death, intracellular stress responses, survival signaling pathways, and cellular adaptation.

Peptide Pharmacology

Researchers utilize ARA-290 for receptor characterization, peptide stability studies, pharmacodynamic investigations, analytical characterization, and structure-function relationship research.

Product Specifications

*Values may vary slightly depending on the counterion (e.g., acetate or TFA salt form).

Mechanism of Action

ARA-290 (Cibinetide) Peptide is a synthetic peptide modeled after the helix-B surface of erythropoietin (EPO) and is specifically engineered to activate the Innate Repair Receptor (IRR) without engaging the homodimeric erythropoietin receptor responsible for erythropoiesis. The IRR consists of a heteromeric receptor complex formed by the erythropoietin receptor (EPOR) and the β-common receptor (CD131). This selective receptor interaction enables researchers to investigate non-erythropoietic EPO signaling while minimizing activation of pathways associated with red blood cell production.

Upon binding to the IRR, ARA-290 initiates intracellular signaling cascades involving Janus kinase 2 (JAK2) activation followed by phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins, particularly STAT3 and STAT5. These signaling events regulate transcriptional programs involved in cellular adaptation, stress responses, and maintenance of tissue homeostasis within experimental models.

Published laboratory research has also demonstrated activation of phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK/ERK) pathways following IRR stimulation. These intracellular signaling networks coordinate cellular survival responses, mitochondrial homeostasis, protein synthesis regulation, and modulation of oxidative stress signaling. Researchers continue investigating how these pathways contribute to peptide-mediated cellular communication under controlled laboratory conditions.

Additional investigations have examined ARA-290’s influence on inflammatory signaling pathways involving nuclear factor-kappa B (NF-κB), cytokine regulation, and expression of inflammatory mediators such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Experimental studies also evaluate interactions with apoptotic signaling proteins, mitochondrial membrane stability, and intracellular redox regulation to better understand mechanisms governing cellular resilience and adaptive responses.

Because ARA-290 selectively activates the Innate Repair Receptor without stimulating classical erythropoietic signaling, it has become an important research reagent for molecular pharmacology, immunology, neuroscience, peptide chemistry, regenerative biology, and biotechnology laboratories investigating receptor biology, intracellular signaling, and cellular homeostasis.

For research use only. Not intended for human consumption or clinical use.